Mixed phenotype acute leukemia (MPAL) is an uncommon type of leukemia. It is one kind of malignant clonal diseases that expresses more than one genealogical specific antigen simultaneously. Most MPAL patients are associated with clonal chromosomal abnormalities and molecular genetic changes, such as t(9;22) (q34;q11) and KMT2A (MLL) rearrangement. These specific abnormalities usually have important guiding significance in MPAL diagnosis, targeted therapy and prognosis judgment. In this paper, we reported a case of MPAL, T/myeloid (M5) with an unfrequent combination of PML-RARα positivity and t(15;17). The treatment was successful with chemotherapy for both AML and ALL with daunorubicin, cytarabine (DA) and vincristine, prednisone (VP). We reported here this suggestive MPAL case of rare disease condition and effective treatment, in order to provide experience for the early diagnosis and treatment of similar patients.

中文翻译：

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PML-RARα阳性的混合表型急性白血病：一例病例报告并文献复习

混合表型急性白血病（MPAL）是一种罕见的白血病。同时表达一种以上家谱特异性抗原的恶性克隆疾病是一种。大多数MPAL患者与克隆染色体异常和分子遗传学改变有关，例如t（9; 22）（q34; q11）和KMT2A（MLL）重排。这些特异性异常通常对MPAL诊断，靶向治疗和预后判断具有重要的指导意义。在本文中，我们报道了一例MPAL，T /髓样（M5）与PML-RARα阳性和t（15; 17）很少合并的情况。柔红霉素阿糖胞苷（DA）和长春新碱，泼尼松（VP）对AML和ALL的化疗均成功治疗。我们在这里报告了这例提示MPAL的罕见疾病，并进行了有效治疗，