Depression and apathy can be significant problems in progressive supranuclear palsy (PSP). Using PRISMA guidelines, this systematic review examined prevalence estimates for depression and apathy in PSP, and, how different methods of definition may influence results. 29 studies meeting inclusion/exclusion criteria were identified: 12 on depression, 9 on apathy, and 8 on both. Studies were stratified according to whether a diagnostic criteria, rating scale or screening question methodology was employed. The weighted mean prevalence was 59.7% for depression (sample size = 473) and 58.3% for apathy (sample size = 858). Results for depression using diagnostic criteria or rating scales were similar whereas screening questions were associated with considerable inconsistency. Depression prevalence appeared to be influenced by apathy but not somatic symptoms. Most apathy studies relied only on a screening question method. Depression and apathy are common in PSP but there is a need for consensus on how they are defined (both tools and cut-off scores). In particular, more studies probing apathy in greater detail than a simple screening question are required.

抑郁和冷漠可能是进行性核上性麻痹 (PSP) 的重要问题。使用 PRISMA 指南，本系统评价检查了 PSP 中抑郁和冷漠的患病率估计，以及不同的定义方法如何影响结果。确定了 29 项符合纳入/排除标准的研究：12 项关于抑郁症，9 项关于冷漠，8 项关于两者。根据是否采用诊断标准、评定量表或筛选问题方法对研究进行分层。抑郁症的加权平均患病率为 59.7%（样本量 = 473），冷漠为 58.3%（样本量 = 858）。使用诊断标准或评定量表的抑郁症结果相似，而筛查问题与相当大的不一致相关。抑郁症的患病率似乎受到冷漠的影响，但不受躯体症状的影响。大多数冷漠研究仅依赖于筛选问题方法。抑郁和冷漠在 PSP 中很常见，但需要就如何定义它们（工具和截止分数）达成共识。特别是，需要更多的研究比简单的筛选问题更详细地探讨冷漠。