In recent years, the development of diverse CRISPR-based technologies has revolutionized genome manipulation and enabled a broad scientific community in industry, academia, and beyond to redefine research and development for biotechnology products encompassing food, agriculture, and medicine. CRISPR-based genome editing affords tremendous opportunities in agriculture for the breeding of crops and livestock across the food supply chain that could benefit larger portions of the population compared to CRISPR applications in medicine, for example by helping to feed a growing global population, reach sustainability goals, and possibly mitigate the effects of climate change. These promises come alongside concerns of risks and adverse impacts associated with CRISPR-based genome editing and concerns that governance systems that are ill equipped or not well suited to evaluate these risks. The international community will continue to gather, in multiple venues, in the coming years to discuss these concerns. At the same time, responsible research and innovation paradigms also promise to evaluate the risks and benefits better while incorporating broad stakeholder engagement across the research and development process. The CRISPR community therefore must actively engage with these international deliberations, society, and national governance systems that have promised to build better agricultural systems and provide better food products to achieve equitable outcomes while protecting the environment. Without this active engagement, the promises discussed in this paper are sure to be broken.

中文翻译：

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（破碎的）通过新生物技术实现可持续粮食和农业的承诺：CRISPR 案例

近年来，基于 CRISPR 的多种技术的发展彻底改变了基因组操作，并使工业界、学术界等广泛的科学界能够重新定义包括食品、农业和医药在内的生物技术产品的研发。基于 CRISPR 的基因组编辑为整个食品供应链中农作物和牲畜的育种提供了巨大的农业机会，与医学中的 CRISPR 应用相比，可以使更多人口受益，例如通过帮助养活不断增长的全球人口，实现可持续性目标，并可能减轻气候变化的影响。这些承诺伴随着对与基于 CRISPR 的基因组编辑相关的风险和不利影响的担忧，以及对装备不良或不适合评估这些风险的治理系统的担忧。未来几年，国际社会将继续在多个场所聚集在一起讨论这些关切。与此同时，负责任的研究和创新范式还承诺更好地评估风险和收益，同时将广泛的利益相关者参与纳入整个研发过程。因此，CRISPR 社区必须积极参与这些国际审议、社会和国家治理系统，这些系统承诺建立更好的农业系统并提供更好的食品，以在保护环境的同时实现公平的结果。