Manipulating Phospholipid Vesicles at the Nanoscale: A Transformation from Unilamellar to Multilamellar by an n-Alkyl-poly(ethylene oxide),Langmuir

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Manipulating Phospholipid Vesicles at the Nanoscale: A Transformation from Unilamellar to Multilamellar by an n-Alkyl-poly(ethylene oxide)
Langmuir ( IF 3.7 ) Pub Date : 2021-02-11 , DOI: 10.1021/acs.langmuir.0c03302
Judith U De Mel , Sudipta Gupta , Lutz Willner ₁ , Jürgen Allgaier ₁ , Laura R Stingaciu ₂ , Markus Bleuel ₃ , Gerald J Schneider

Affiliation

We investigated the influence of an n-alkyl-PEO polymer on the structure and dynamics of phospholipid vesicles. Multilayer formation and about a 9% increase in the size in vesicles were observed by cryogenic transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), and small-angle neutron/X-ray scattering (SANS/SAXS). The results indicate a change in the lamellar structure of the vesicles by a partial disruption caused by polymer chains, which seems to correlate with about a 30% reduction in bending rigidity per unit bilayer, as revealed by neutron spin echo (NSE) spectroscopy. Also, a strong change in lipid tail relaxation was observed. Our results point to opportunities using synthetic polymers to control the structure and dynamics of membranes, with possible applications in technical materials and also in drug and nutraceutical delivery.

中文翻译：

在纳米尺度上操纵磷脂囊泡：正烷基聚环氧乙烷从单层到多层的转变

我们研究了正烷基聚环氧乙烷聚合物对磷脂囊泡结构和动力学的影响。通过低温透射电子显微镜 (cryo-TEM)、动态光散射 (DLS) 和小角中子/X 射线散射 (SANS/SAXS) 观察到多层形成和囊泡尺寸增加约 9%。结果表明，由于聚合物链造成的部分破坏，囊泡的层状结构发生了变化，这似乎与每单位双层的弯曲刚度降低了约 30% 有关，正如中子自旋回波 (NSE) 光谱所揭示的那样。此外，还观察到脂质尾松弛的强烈变化。我们的结果指出了使用合成聚合物来控制膜的结构和动力学的机会，可能应用于技术材料以及药物和营养保健品的输送。

更新日期：2021-02-23

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