Alterations in composition of human gut microbiome can lead to its dysbiosis. It is associated with gastrointestinal side effects during anti-cancer treatment, antibiotics administration, or infectious agents. There are studies confirming positive effect of consuming Lactobacillus plantarum 299v on intestinal microflora. This review summarizes the current knowledge about the role of L. plantarum 299v in supporting treatment of selected diseases, such as cancer, irritable bowel syndrome (IBS), and Clostridium difficile infection. The immunomodulating properties of L. plantarum 299v include an increase in the level of anti-inflammatory cytokines, which reduce the risk of cancer and improve the efficacy of regimens. The intake of L. plantarum 299v provides benefits for IBS patients, mainly due to normalization of stool and relief of abdominal pain, which significantly improves the quality of life of IBS patients. In addition, the intake of L. plantarum 299v prevents C. difficile-associated diarrhea among patients receiving antibiotic treatment. Due to the limited possibilities of treating these diseases and numerous complications of cancer treatment, there is a need for new therapeutic strategies. The administration of L. plantarum 299v seems to be useful in these cases.

中文翻译：

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植物乳杆菌299v在支持治疗某些疾病中的作用

人类肠道微生物组组成的改变可导致其营养不良。它与抗癌治疗，抗生素施用或感染性药物的胃肠道副作用有关。有研究证实食用植物乳杆菌299v对肠道菌群有积极作用。这篇综述总结了有关植物乳杆菌299v在支持某些疾病（例如癌症，肠易激综合征（IBS）和艰难梭菌感染）治疗中的作用的最新知识。植物乳杆菌299v的免疫调节特性包括抗炎细胞因子水平的增加，这降低了癌症的风险并改善了方案的功效。摄入植物乳杆菌299v可为IBS患者带来益处，这主要是由于粪便正常化和腹痛减轻，这大大改善了IBS患者的生活质量。另外，摄入植物乳杆菌299v可防止接受抗生素治疗的患者艰难梭菌相关性腹泻。由于治疗这些疾病的可能性有限以及癌症治疗的众多并发症，因此需要新的治疗策略。在这些情况下，植物乳杆菌299v的给药似乎是有用的。