Abstract

Although the prevalence of metabolic syndrome (MetS), a cluster of cardiometabolic risk factors that predispose to the development of type 2 diabetes mellitus and cardiovascular diseases, is increasing globally, there is no broad-spectrum agent for its holistic treatment. Natural plant-derived products with a wide spectrum of biological activities are currently being explored as alternatives in the management of diseases. Artemisia species are a heterozygous group of plants of the Compositae family that possess several health benefits. Here we highlight their antidiabetic, anti-obesity, anti-hyperlipidaemic, hepatoprotective and cardioprotective properties among others. These activities have been linked to the presence of phytochemicals that act on several molecular targets to exert their effects and the species of Artemisia are considered to be relatively safe. Artemisia species offer significant anti-MetS activity and thus are strong therapeutic candidates for the effective management of MetS.

摘要

尽管代谢综合征 (MetS) 的患病率在全球范围内呈上升趋势，这是一组易导致 2 型糖尿病和心血管疾病发展的心脏代谢危险因素，但目前尚无可对其进行整体治疗的广谱药物。目前正在探索具有广泛生物活性的天然植物衍生产品作为疾病管理的替代品。蒿属是菊科植物的杂合子群具有多种健康益处的家庭。在这里，我们重点介绍它们的抗糖尿病、抗肥胖、抗高血脂、保肝和心脏保护等特性。这些活动与植物化学物质的存在有关，这些植物化学物质作用于多个分子靶标以发挥其作用，而蒿属物种被认为是相对安全的。蒿属物种具有显着的抗 MetS 活性，因此是有效管理 MetS 的强有力的治疗候选物。