ABSTRACT

Introduction: Today, the development of multifunctional nanoplatforms is more seriously considered in the field of cancer theranostics.

Areas covered: In this respect, nanoparticles provide several advantages over the routine, conventional diagnostic methods, and treatments. Due to the expedient properties of iron oxide nanoparticles, such as being readily modified, great payload potential, intrinsic magnetic qualification, considerable biocompatibility, and overwhelming response to targeting strategies, these nanoparticles can be considered good candidates for application as diagnostic contrast agents and drug/gene delivery vehicles, while also being incorporated into hyperthermia-based approaches. Interestingly, these agents are detectable with routine imaging modalities such as magnetic resonance imaging.

Expert opinion: Therefore, combining the traditional diagnostics and therapies with nanotechnological approaches may leave a positive impact on the survival rate of patients with cancer. This review summarizes the application of magnetic iron oxide nanoparticles in both in vitro and in vivo models of brain tumors.

摘要

简介：如今，多功能纳米平台的开发在癌症治疗诊断领域得到了更为认真的考虑。

涵盖的领域：在这方面，纳米粒子比常规的常规诊断方法和治疗具有多种优势。由于氧化铁纳米粒子的便利特性，例如易于修饰、有效载荷潜力大、内在磁性限定、相当大的生物相容性以及对靶向策略的压倒性反应，这些纳米粒子可以被认为是用作诊断造影剂和药物/基因传递载体，同时也被纳入基于热疗的方法中。有趣的是，这些试剂可通过常规成像方式（如磁共振成像）检测到。

专家意见：因此，将传统的诊断和治疗方法与纳米技术方法相结合，可能会对癌症患者的生存率产生积极影响。本综述总结了磁性氧化铁纳米粒子在脑肿瘤体外和体内模型中的应用。