A highly efficient and catalyst-free protocol is reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds. Remarkably simple and green reaction conditions employing methanol as solvent afforded medium to excellent yield of quinoxalines after only one-minute reaction time at ambient temperature. The conditions allow at least 10 gram scale synthesis of quinoxalines and should be a preferred starting point for optimization and method of choice for applications in the synthetic community.

中文翻译：

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一种绿色，可扩展且无催化剂的一分钟合成喹喔啉

据报道，通过芳基二胺和二羰基化合物之间的经典环缩合反应，可以高效，无催化剂地合成喹喔啉。在室温下仅一分钟的反应时间之后，使用甲醇作为溶剂的非常简单和绿色的反应条件提供了中等至优异的喹喔啉产率。该条件允许至少10克规模的喹喔啉合成，并且应该是优化的首选起点，并且是合成社区中应用的首选选择方法。