Acute gastroenteritis remains a significant cause of morbidity and mortality both in high and low-resource settings. The development of nucleic acid based testing has demonstrated that viruses are a common, yet often undetected, cause of acute gastroenteritis. The development of multiplex pathogen PCR panels makes it possible to detect these viral pathogens with greater sensitivity and rapidity than with previous methods. At present, there is insufficient evidence to recommend the routine use of these panels for the average patient with acute gastroenteritis. However, there are specific scenarios and patient populations such as epidemiology/outbreak surveillance, antimicrobial stewardship, and the care of immunocompromised patients where these tests could be clinically useful today. Further research on the effect of these syndromic panels on provider antibiotic prescribing behavior and patient length of stay will be necessary in order to know their ultimate role in clinical practice.

中文翻译：

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多重病原体检测对诊断急性病毒性胃肠炎的临床意义


急性胃肠炎仍然是资源丰富和匮乏地区发病和死亡的重要原因。基于核酸的检测的发展表明，病毒是急性胃肠炎的常见原因，但往往未被发现。多重病原体 PCR 组合的开发使得比以前的方法更灵敏、更快速地检测这些病毒病原体成为可能。目前，没有足够的证据建议普通急性胃肠炎患者常规使用这些组合。然而，在某些特定情况和患者群体中，例如流行病学/疫情监测、抗菌药物管理以及免疫功能低下患者的护理，这些测试今天可能在临床上有用。为了了解它们在临床实践中的最终作用，有必要进一步研究这些综合征组对提供者抗生素处方行为和患者住院时间的影响。