This article describes our research work for the past decade, which involves the transition-metal-catalyzed cyclization reactions of the C−N multiple bonds containing species and their synthetic applications to access various heterocyclic compounds. The concepts of reactions including four types of coupling with a subsequent cyclization are (1) the transition-metal performs as a Lewis acid to activate a nitrile and accelerate the nucleophilic addition, (2) the transition-metal-catalyzed 1,2-insertion reaction of nitrile, (3) the Cu-catalyzed C−N coupling reaction of imine, and (4) the Co-catalyzed addition/cyclization reaction of imine. These methods can be used to synthesize various N-containing aromatic heterocycles with higher efficiency, and can be applied to the synthesis of relevent natural alkaloids, their derivatives as well as biologically active compounds.

中文翻译：

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包含物质的 CN 多键的过渡金属催化的加成/环化反应

本文介绍了我们过去十年的研究工作，涉及过渡金属催化的含 CN 多键的物种的环化反应及其合成应用以获取各种杂环化合物。包括四种偶联与随后环化反应的概念是 (1) 过渡金属作为路易斯酸激活腈并加速亲核加成，(2) 过渡金属催化的 1,2-插入腈的反应，(3) Cu 催化的亚胺 CN 偶联反应，和 (4) Co 催化的亚胺加成/环化反应。这些方法可用于合成各种含氮芳香杂环，效率更高，可应用于相关天然生物碱的合成，