The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is present in a large number of biologically active molecules, including several drugs currently in the market. Due to their vast applications, a wide variety of methods are described for their preparation, such as the 1,3-dipolar cycloaddition and processes involving diazo compounds and diazo transfer reactions. Considering the significant number of contributions from our research group to this chemistry in recent decades, in this account we discuss both the development of new methods for the synthesis of 1,2,3-triazoles and the preparation of new triazole-functionalized biologically active molecules using classical approaches.

中文翻译：

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生物活性 1,2,3-三唑：对其合成、结构多样性和生物应用的说明

三唑杂环是药物化学中的一种特殊支架，因为它的结构存在于大量生物活性分子中，包括目前市场上的几种药物。由于它们的广泛应用，描述了它们的制备方法多种多样，例如 1,3-偶极环加成以及涉及重氮化合物和重氮转移反应的过程。考虑到近几十年来我们的研究小组对该化学做出的大量贡献，在这个帐户中，我们讨论了合成 1,2,3-三唑的新方法的开发和新的三唑官能化生物活性分子的制备使用经典方法。