Preparation of ordered macroporous molecularly imprinted polymers and their applications in purifying cinchona alkaloids from cinchona extract,Polymer International

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Preparation of ordered macroporous molecularly imprinted polymers and their applications in purifying cinchona alkaloids from cinchona extract
Polymer International ( IF 2.9 ) Pub Date : 2021-02-11 , DOI: 10.1002/pi.6205
Zhi‐Yuan Zhang ₁ , Li‐Li Rui ₁ , Ya‐Li Lin ₁ , Hui‐Dan Zhang ₁ , Ji‐Ming Ou ₁ , Jian‐Feng He ₁ , Quan‐Zhou Wu ₁

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Three-dimensionally ordered macroporous molecularly imprinted polymers (3DOM MIPs) were prepared for the direct purification of cinchona alkaloids from crude cinchona extract. The 3DOM MIPs were easily prepared by grafting quinine-MIPs on the pore walls of 3DOM thiol-group-functionalized silica. The materials were characterized using various techniques. The results showed that the 3DOM MIPs had a more regular macroporous structure, a greater surface area and a greater porosity than traditional bulk MIPs (TBMIPs). The 3DOM MIPs could reach a high MIP content of 69.9%. And the 3DOM structure could improve intraparticle adsorption and provide more accessible adsorption sites. Consequently, in both static adsorption experiments and solid-phase extraction (SPE), the actual adsorption capacity of the imprinted polymers of the 3DOM MIPs was about 83% higher than that of TBMIPs. Moreover, the 3DOM MIPs exhibited high affinity for quinine, quinidine and cinchonine. Using the quinine-3DOM MIPs as SPE sorbent, quinine, quinidine and cinchonine could be effectively purified from crude cinchona extract with high elution recoveries. Control experiments also showed that the 3DOM MIPs were superior to commercially available adsorbents in terms of the purification of cinchona alkaloids from crude extract. Â© 2021 Society of Chemical Industry

中文翻译：

有序大孔分子印迹聚合物的制备及其在金鸡纳提取物中纯化金鸡纳生物碱中的应用

制备了三维有序的大孔分子印迹聚合物 (3DOM MIPs)，用于从金鸡纳粗提取物中直接纯化金鸡纳生物碱。通过在 3DOM 硫醇基官能化二氧化硅的孔壁上接枝奎宁 MIP，可以轻松制备 3DOM MIP。使用各种技术表征材料。结果表明，与传统的块状 MIP（TBMIP）相比，3DOM MIP 具有更规则的大孔结构、更大的表面积和更大的孔隙率。3DOM MIP 可以达到 69.9% 的高 MIP 含量。并且 3DOM 结构可以改善颗粒内吸附并提供更容易接近的吸附位点。因此，在静态吸附实验和固相萃取 (SPE) 中，3DOM MIPs 印迹聚合物的实际吸附能力比 TBMIPs 高约 83%。此外，3DOM MIP 对奎宁、奎尼丁和辛可宁表现出高亲和力。使用奎宁-3DOM MIP 作为 SPE 吸附剂，奎宁、奎尼丁和辛可宁可以从金鸡纳粗提物中有效纯化，洗脱回收率高。对照实验还表明，在从粗提物中纯化金鸡纳生物碱方面，3DOM MIP 优于市售吸附剂。© 2021 化学工业协会对照实验还表明，在从粗提物中纯化金鸡纳生物碱方面，3DOM MIP 优于市售吸附剂。© 2021 化学工业协会对照实验还表明，在从粗提物中纯化金鸡纳生物碱方面，3DOM MIP 优于市售吸附剂。© 2021 化学工业协会

更新日期：2021-02-11

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