Ubiquitination is a key posttranslational modification for the controlled protein degradation and proteostasis. The substrate specificity is determined by a family of E3 ubiquitin ligases, which are encoded by more than 600 genes in the mammalian genome. Gain- or loss-of-function of a number of E3 genes results in neurodegeneration or neurodevelopmental disorders, affecting synapse function. This implies that the specific ubiquitination of synaptic substrates are of crucial importance for the normal neuronal network. In this review, we will summarize the history, current topics, and challenges in the field of ubiquitination-dependent regulations of synaptogenesis and synaptic transmission.

泛素化是控制蛋白质降解和蛋白质稳态的关键翻译后修饰。底物特异性由 E3 泛素连接酶家族决定，该家族由哺乳动物基因组中的 600 多个基因编码。许多 E3 基因的功能获得或丧失会导致神经变性或神经发育障碍，从而影响突触功能。这意味着突触底物的特定泛素化对于正常神经元网络至关重要。在这篇综述中，我们将总结泛素化依赖性突触发生和突触传递调控领域的历史、当前主题和挑战。