TIPE-2 has been identified as a negative regulator of both innate and adaptive immunity and is involved in several inflammatory diseases. However, the role of immune suppression of dendritic cells (DCs) transduced with TIPE-2 has not been well studied. In this study, DCs were transduced with TIPE-2 recombinant adenovirus, and then were cocultured with allogeneic CD4+ or CD8 + T cells. The proliferation, cytokine production and activation marker levels of CD4+ or CD8 + T cell were detected. The data demonstrated that T cell proliferation, cytokine production and activation marker levels were attenuated after treated with TIPE-2 transduced DCs. These results suggested that TIPE-2 transduced DCs are capable of inducing allogeneic CD4+ or CD8 + T cell immune suppression, which provide a promising way for the therapeutical strategies of transplantation or autoimmune diseases.

中文翻译：

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TIPE-2重组腺病毒转导的树突状细胞诱导T细胞抑制

TIPE-2已被鉴定为先天和适应性免疫的负调节剂，并参与多种炎症性疾病。但是，尚未充分研究TIPE-2转导的树突状细胞（DC）的免疫抑制作用。在这项研究中，DCs用TIPE-2重组腺病毒转导，然后与同种异体CD4 +或CD8 + T细胞共培养。检测CD4 +或CD8 + T细胞的增殖，细胞因子产生和激活标记物水平。数据表明，用TIPE-2转导的DC处理后，T细胞增殖，细胞因子产生和激活标记物水平降低。这些结果表明TIPE-2转导的DC能够诱导同种CD4 +或CD8 + T细胞免疫抑制，