Contrast-Enhanced Sonography with Biomimetic Lung Surfactant Nanodrops,Langmuir

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Contrast-Enhanced Sonography with Biomimetic Lung Surfactant Nanodrops
Langmuir ( IF 3.7 ) Pub Date : 2021-02-10 , DOI: 10.1021/acs.langmuir.0c03349
Alec N Thomas _{1,

2} , Kang-Ho Song ₁ , Awaneesh Upadhyay ₁ , Virginie Papadopoulou ₃ , David Ramirez ₄ , Richard K P Benninger ₄ , Matthew Lowerison _{5,

6} , Pengfei Song _{5,

6} , Todd W Murray _{1,

7} , Mark A Borden _{1,

7}

Affiliation

Nanodrops comprising a perfluorocarbon liquid core can be acoustically vaporized into echogenic microbubbles for ultrasound imaging. Packaging the microbubble in its condensed liquid state provides some advantages, including in situ activation of the acoustic signal, longer circulation persistence, and the advent of expanded diagnostic and therapeutic applications in pathologies which exhibit compromised vasculature. One obstacle to clinical translation is the inability of the limited surfactant present on the nanodrop to encapsulate the greatly expanded microbubble interface, resulting in ephemeral microbubbles with limited utility. In this study, we examine a biomimetic approach to stabilize an expanding gas surface by employing the lung surfactant replacement, beractant. Lung surfactant contains a suite of lipids and proteins that provide efficient shuttling of material from bilayer folds to the monolayer surface. We hypothesized that beractant would improve stability of acoustically vaporized microbubbles. To test this hypothesis, we characterized beractant surface dilation mechanics and revealed a novel biophysical phenomenon of rapid interfacial melting, spreading, and resolidification. We then harnessed this unique functionality to increase the stability and echogenicity of microbubbles produced after acoustic droplet vaporization for in vivo ultrasound imaging. Such biomimetic lung surfactant-stabilized nanodrops may be useful for applications in ultrasound imaging and therapy.

中文翻译：

用仿生肺表面活性剂纳米滴剂进行对比增强超声检查

包含全氟化碳液芯的纳米液滴可以声学汽化成回声微泡，用于超声成像。将微泡包装在其冷凝液体状态提供了一些优势，包括原位声信号的激活、更长的循环持续时间以及在表现出血管系统受损的病理中扩展诊断和治疗应用的出现。临床转化的一个障碍是纳米滴上存在的有限表面活性剂无法封装大大扩展的微泡界面，导致短暂的微泡效用有限。在这项研究中，我们研究了一种仿生方法，通过使用肺表面活性剂替代物 beractant 来稳定膨胀的气体表面。肺表面活性剂含有一系列脂质和蛋白质，可有效地将材料从双层折叠层穿梭到单层表面。我们假设 beractant 会提高声学汽化微泡的稳定性。为了检验这个假设，我们描述了beractant表面膨胀力学，并揭示了一种新的快速界面熔化、扩散和再凝固的生物物理现象。然后，我们利用这种独特的功能来提高声学液滴汽化后产生的微泡的稳定性和回声性体内超声成像。这种仿生肺表面活性剂稳定的纳米滴剂可用于超声成像和治疗中的应用。

更新日期：2021-02-23

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