Methods

We administered the Global Neuropsychological Assessment (GNA), an abbreviated cognitive battery, to 105 adults aged 73.0 ± 7.1 years, including 28 with probable Alzheimer’s disease, 9 with amnestic mild cognitive impairment, and 68 healthy controls. We examined group differences in baseline performance, test–retest reliability, and correlations with other conventional tests.

Results

Healthy adults outperformed patients on all five GNA subtests. Test–retest intraclass correlation coefficients were significant for all GNA subtests. Among patients with healthy controls, GNA Story Memory correlated best with Wechsler Memory Scale–Revised (WMS-R) Logical Memory for learning and delayed recall, GNA Digit Span correlated most highly with the Wechsler Adult Intelligence Scale–Third Edition (WAIS-III) Digit Span, GNA Perceptual Comparison correlated most highly with the Trail Making Test, and GNA Animal Naming correlated most highly with Supermarket Item Naming.

Conclusions

Preliminary findings suggest that the GNA shows good test–retest validity, clear convergent and discriminant construct validity, and excellent diagnostic criterion validity for dementia and mild cognitive impairment in an American sample.

中文翻译：

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阿尔茨海默病和健康志愿者全球神经心理学评估的初步验证

方法

我们对 105 名年龄为 73.0 ± 7.1 岁的成年人进行了全球神经心理学评估 (GNA)，其中包括 28 名可能患有阿尔茨海默病、9 名患有遗忘性轻度认知障碍和 68 名健康对照者。我们检查了基线表现、重测信度以及与其他常规测试的相关性方面的组差异。

结果

在所有五项 GNA 子测试中，健康成人的表现都优于患者。所有 GNA 子测试的重测组内相关系数均显着。在健康对照的患者中，GNA 故事记忆与韦氏记忆量表修订版 (WMS-R) 学习和延迟回忆逻辑记忆的相关性最高，GNA 数字跨度与韦氏成人智力量表第三版 (WAIS-III) 的相关性最高数字跨度、GNA 感知比较与 Trail Making Test 相关性最高，而 GNA 动物命名与超市商品命名相关性最高。

结论

初步研究结果表明，在美国样本中，GNA 显示出良好的重测效度、明确的收敛和区分结构效度以及对痴呆和轻度认知障碍的出色诊断标准效度。