Abstract

Current fossil-based commercial products pose a serious threat to global reserves of natural resources and the preservation of the natural environment. During recent decades, great efforts have been made to increase the availability of non-utilizable biomass as alternative feedstocks and reduce environmental pollution to achieve a more sustainable bioeconomy. Several bio-sectors have emerged for the production of bio-based products to replace fossil-based equivalents through bioprocesses using biomass feedstocks. Indeed, advanced microbial fermentation technologies encompassing metabolic engineering and genome-based systems biology approaches have enabled the design and development of new bio-based refineries using engineered platform cells. Herein, we focus on recent progress in the area of microbial fermentation-aided bioprocesses for the production of bio-based products derived from naturally occurring biomasses as feedstocks. Furthermore, we discuss the application of bio-based products and remaining technical barriers and assess possible biorefineries.

摘要

当前基于化石的商业产品对全球自然资源储备和自然环境保护构成严重威胁。近几十年来，人们做出了巨大的努力来增加不可利用的生物质作为替代原料的可用性，并减少环境污染，以实现更可持续的生物经济。已经出现了几个生物部门，用于生产生物基产品，以通过使用生物质原料的生物工艺替代基于化石的等价物。事实上，包括代谢工程和基于基因组的系统生物学方法在内的先进微生物发酵技术已经使使用工程平台细胞设计和开发新的生物基炼油厂成为可能。在此处，我们专注于微生物发酵辅助生物工艺领域的最新进展，用于生产以天然生物质为原料的生物基产品。此外，我们讨论了生物基产品的应用和剩余的技术障碍，并评估了可能的生物精炼厂。