Enantioselective recognition of tryptophan isomers with molecularly imprinted overoxidized polypyrrole/poly(p‐aminobenzene sulfonic acid) modified electrode,Chirality

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Enantioselective recognition of tryptophan isomers with molecularly imprinted overoxidized polypyrrole/poly(p‐aminobenzene sulfonic acid) modified electrode
Chirality ( IF 2.8 ) Pub Date : 2021-02-10 , DOI: 10.1002/chir.23299
Ling Gong _{1,

2} , Shan Li ₁ , Zhengzhi Yin ₃ , Kelin Li ₁ , Jiawei Gu ₁ , Datong Wu ₁ , Yong Kong ₁

Affiliation

Poly(p‐aminobenzene sulfonic acid) (pABSA) was electrodeposited onto the surface of a glassy carbon electrode (GCE), which was then used for the preconcentration of l‐tryptophan (l‐Trp) due to the electrostatic and π–π interactions between pABSA and l‐Trp. Polypyrrole (PPy) was electrodeposited onto the surface of the l‐Trp enriched pABSA, and then the l‐Trp templates were removed, resulting in molecularly imprinted PPy/pABSA. To avoid the interference from the oxidation peak of PPy on the following electrochemical chiral recognition of Trp isomers, PPy was overoxidized by cyclic voltammetry (CV). The resultant molecularly imprinted overoxidized PPy (OPPy)/pABSA modified GCE exhibits higher affinity toward l‐Trp than d‐tryptophan (d‐Trp); that is, the oxidation peak current of l‐Trp is greatly higher than that of d‐Trp at the molecularly imprinted OPPy/pABSA modified GCE.

中文翻译：

分子印迹过氧化聚吡咯/聚对氨基苯磺酸修饰电极对色氨酸异构体的对映选择性识别

将聚对氨基苯磺酸 (pABSA) 电沉积到玻碳电极 (GCE) 表面，然后通过静电和 π-π 相互作用将其用于预富集l-色氨酸 ( l -Trp) pABSA 和l -Trp 之间。将聚吡咯（PPy）电沉积到富含l -Trp 的 pABSA 表面，然后去除l -Trp 模板，形成分子印迹 PPy/pABSA。为了避免PPy的氧化峰对随后Trp异构体的电化学手性识别的干扰，通过循环伏安法（CV）对PPy进行过氧化。所得分子印迹过氧化 PPy (OPPy)/pABSA 修饰的 GCE 对l -Trp 的亲和力比对d-色氨酸 ( d -Trp) 的亲和力更高；也就是说，在分子印迹OPPy/pABSA修饰的GCE上， l -Trp的氧化峰电流大大高于d -Trp的氧化峰电流。

更新日期：2021-03-09

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