The rise in the number of daily surgical procedures and the disadvantages posed by the present surgical closure techniques (such as secondary tissue damage and microbial infection) magnifies the immediate need for metamorphosing the current bioadhesives perceiving to tether wounds efficiently. To this context, the emerging scope of biomimetics has allowed mussel inspired adhesives rendering efficient bonding characteristics on a variety of substrates. The mussel adhesion proteins and its derivatives, such as 3,4-dihydroxyphenylalanine and dopamine, are therefore widely being studied to modify the biopolymers, attempting to enhance the adhesive attributes. The polarity of the catechol groups in the protein conformation aids in the development of both noncovalent interactions (electrostatic interaction, hydrogen bonding, metal/ligand coordination bond, π-π/cation-π interactions) and covalent interactions (crosslinking), thereby promoting superior tissue adhesion. This narrative is an attempt to tether the recent developments in the mussel-inspired polymer adhesives, connecting the footprints of how these materials evolved with its current state of the art.

日常外科手术的数量的增加以及当前外科闭合技术所带来的缺点（例如继发性组织损伤和微生物感染）放大了迫切需要使当前生物粘合剂有效地变形以感知系绳伤口的需求。就此而言，仿生学的新兴范围已使贻贝启发的粘合剂在各种基材上呈现出有效的粘合特性。因此，广泛研究贻贝粘附蛋白及其衍生物，例如3,4-二羟基苯丙氨酸和多巴胺，以修饰生物聚合物，试图增强粘附特性。蛋白质构象中的邻苯二酚基团的极性有助于两个非共价相互作用（静电相互作用，氢键，金属/配体配位键，π-π/阳离子-π相互作用）和共价相互作用（交联），从而促进优异的组织粘附。这种叙述是试图将以贻贝为灵感的聚合物胶粘剂的最新发展束缚起来，将这些材料如何发展的足迹与当前的技术水平联系起来。