Vertebrates have adapted to life on Earth and its constant gravitational field, which exerts load on the body and influences the structure and function of tissues. While the effects of microgravity on muscle and bone homeostasis are well described, with sarcopenia and osteoporosis observed in astronauts returning from space, the effects of shorter exposures to increased gravitational fields are less well characterized. We aimed to test how hypergravity affects early cartilage and skeletal development in a zebrafish model.

中文翻译：

---

在斑马鱼发育过程中暴露于超重力会改变软骨材料特性和应变分布。

脊椎动物已经适应了地球上的生命及其恒定的重力场，它对身体施加负荷并影响组织的结构和功能。虽然微重力对肌肉和骨骼稳态的影响得到了很好的描述，但在从太空返回的宇航员中观察到肌肉减少症和骨质疏松症，但较短时间暴露于增加的重力场的影响却没有得到很好的表征。我们旨在测试超重力如何影响斑马鱼模型中的早期软骨和骨骼发育。