The high prevalence of osteoarthritis (OA), as well as the current lack of disease-modifying drugs for OA, has provided a rationale for regenerative medicine as a possible treatment modality for OA treatment. In this editorial, the current status of regenerative medicine in OA including stem cells, exosomes, and genes is summarized along with the author's perspectives. Despite a tremendous interest, so far there is very little evidence proving the efficacy of this modality for clinical application. As symptomatic relief is not sufficient to justify the high cost associated with regenerative medicine, definitive structural improvement that would last for years or decades and obviate or delay the need for joint arthroplasty is essential for regenerative medicine to retain a place among OA treatment methods. Cite this article: Bone Joint Res 2021;10(2):134-136.

中文翻译：

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骨关节炎中再生医学的现状。

骨关节炎（OA）的高患病率以及当前缺乏用于OA的疾病改良药物，为再生医学作为OA治疗的一种可能的治疗方式提供了理论依据。在这篇社论中，总结了OA中再生医学的现状，包括干细胞，外泌体和基因，以及作者的观点。尽管有极大的兴趣，但到目前为止，几乎没有证据证明这种方法在临床上的有效性。由于症状缓解不足以证明与再生医学相关的高成本，因此持续数年或数十年并避免或延迟关节置换术的最终结构改善对于再生医学在OA治疗方法中占据一席之地至关重要。引用本文：Bone Joint Res 2021; 10（2）：134-136。