Osteoarthritis (OA), one of the most common motor system disorders, is a degenerative disease involving progressive joint destruction caused by a variety of factors. At present, OA has become the fourth most common cause of disability in the world. However, the pathogenesis of OA is complex and has not yet been clarified. Long non-coding RNA (lncRNA) refers to a group of RNAs more than 200 nucleotides in length with limited protein-coding potential, which have a wide range of biological functions including regulating transcriptional patterns and protein activity, as well as binding to form endogenous small interference RNAs (siRNAs) and natural microRNA (miRNA) molecular sponges. In recent years, a large number of lncRNAs have been found to be differentially expressed in a variety of pathological processes of OA, including extracellular matrix (ECM) degradation, synovial inflammation, chondrocyte apoptosis, and angiogenesis. Obviously, lncRNAs play important roles in regulating gene expression, maintaining the phenotype of cartilage and synovial cells, and the stability of the intra-articular environment. This article reviews the results of the latest research into the role of lncRNAs in a variety of pathological processes of OA, in order to provide a new direction for the study of OA pathogenesis and a new target for prevention and treatment. Cite this article: Bone Joint Res 2021;10(2):122-133.

中文翻译：

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lncRNA在骨关节炎发病机制中的功能。

骨关节炎（OA）是最常见的运动系统疾病之一，是一种变性疾病，涉及由多种因素引起的进行性关节破坏。目前，OA已成为世界上第四大最常见的残疾原因。但是，OA的发病机制很复杂，尚未阐明。长非编码RNA（lncRNA）是指长度超过200个核苷酸且具有有限蛋白质编码潜能的一组RNA，它们具有广泛的生物学功能，包括调节转录模式和蛋白质活性以及结合形成内源性小干扰RNA（siRNA）和天然microRNA（miRNA）分子海绵。近年来，已发现大量lncRNA在OA的各种病理过程中差异表达，包括细胞外基质（ECM）降解，滑膜炎症，软骨细胞凋亡和血管生成。显然，lncRNA在调节基因表达，维持软骨和滑膜细胞表型以及关节内环境的稳定性中起重要作用。本文综述了有关lncRNA在OA各种病理过程中的作用的最新研究结果，从而为OA发病机理的研究提供了新的方向，并为预防和治疗提供了新的靶点。引用本文：本文综述了有关lncRNA在OA各种病理过程中的作用的最新研究结果，从而为OA发病机理的研究提供了新的方向，并为预防和治疗提供了新的靶点。引用本文：本文综述了有关lncRNA在OA各种病理过程中的作用的最新研究结果，从而为OA发病机理的研究提供了新的方向，并为预防和治疗提供了新的靶点。引用本文：Bone Joint Res 2021; 10（2）：122-133。