Traumatic experiences during childhood have been shown to be associated with a higher risk for depressive disorders, more severe symptoms, higher rates of comorbidity, and poorer response to therapy. This study aims to further investigate these links in a clinical sample, focusing especially on therapeutic outcome. Data were collected in a large naturalistic study on inpatient and day hospital treatment of depression at the beginning, the end and after treatment, with this article being a secondary data analysis. Occurrence of childhood trauma, depressive and other symptoms and therapeutic results were compared using robust MANOVA, multiple regression, mixed ANOVA, and Spearman’s correlation. Results provide support for a relationship between childhood trauma and depressive and general symptom severity, the age of onset of depression and the occurrence of personality disorders and somatic diagnoses. There was a significant reduction of depressive symptomatology after therapy. Patients with childhood trauma did not differ significantly from controls in their response to treatment. Clinicians should take the high probability of childhood trauma in depressive patients and the consequent risk of more severe symptoms into account when taking a history and consider adjusting treatment, even if the present data showed that patients generally benefitted from therapy.

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INDDEP研究中儿童期创伤对抑郁的影响

儿童期的创伤经历已显示出与抑郁症风险较高，症状更严重，合并症发生率较高以及对治疗的反应较差有关。这项研究旨在进一步研究临床样品中的这些联系，尤其是治疗结果。在一项大型的自然主义研究中收集了有关抑郁症在开始，结束和治疗后住院和日间医院治疗的数据，本文为辅助数据分析。使用健壮的MANOVA，多元回归，混合ANOVA和Spearman相关性比较了儿童期创伤，抑郁和其他症状的发生率以及治疗效果。结果为儿童创伤与抑郁和一般症状严重程度之间的关系提供了支持，抑郁症的发病年龄以及人格障碍和躯体诊断的发生。治疗后抑郁症状明显减少。儿童期创伤患者对治疗的反应与对照组无显着差异。临床医生应考虑抑郁病史，并考虑到病史并考虑调整治疗，即使目前的数据表明患者通常从治疗中受益，临床医生也应考虑到抑郁症患者发生儿童创伤的可能性很高，并考虑到随之而来的更严重症状的风险。