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Diverse Thiophenes as Scaffolds in Anti-cancer Drug Development: A Concise Review
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2021-01-31 , DOI: 10.2174/1389557520666201202113333 Neha V Bhilare 1 , Pratibha B Auti 2 , Vinayak S Marulkar 1 , Vilas J Pise 1
中文翻译：
多种噻吩类药物在抗癌药物开发中的作用：简要综述。
更新日期：2021-02-09
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2021-01-31 , DOI: 10.2174/1389557520666201202113333 Neha V Bhilare 1 , Pratibha B Auti 2 , Vinayak S Marulkar 1 , Vilas J Pise 1
Affiliation
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Thiophenes are one of the abundantly found heterocyclic ring systems in many biologically active compounds. Moreover, various substituted thiophenes exert numerous pharmacological actions on account of their isosteric resemblance with compounds of natural origin, thus rendering them with diverse actions like antibacterial, antifungal, antiviral, anti-inflammatory, analgesic, antiallergic, hypotensives, etc. In this review, we specifically explore the chemotherapeutic potential of a variety of structures consisting of thiophene scaffolds as prospective anticancer agents.
中文翻译：
多种噻吩类药物在抗癌药物开发中的作用：简要综述。
噻吩是许多生物活性化合物中发现最多的杂环系统之一。此外，各种取代的噻吩由于其与天然化合物的等位相似性而发挥了许多药理作用，因此使其具有多种作用，例如抗菌，抗真菌，抗病毒，抗炎，镇痛，抗过敏，降压药等。在本文中，我们专门研究了由噻吩支架组成的各种结构作为潜在抗癌剂的化学治疗潜力。
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