Background: Head and neck squamous cell carcinoma (HNSCC) are head and neck cancers. On the other hand, ferroptosis is a novel iron-dependent and ROS reliant type of cell death observed various disease conditions./nMethod: We constructed a prognostic multilncRNA signature based on ferroptosis-related differentially expressed lncRNAs in HNSCC./nResults: We identified 25 differently expressed lncRNAs associated with prognosis of HNSCC. Kaplan-Meier analyses revealed the high-risk lncRNAs signature associated with poor prognosis of HNSCC. Moreover, the AUC of the lncRNAs signature was 0.782, underscoring their utility in prediction HNSCC prognosis. Indeed, our risk assessment model was superior to traditional clinicopathological features in predicting HNSCC prognosis. GSEA revealed the immune and tumor-related pathways in the low risk group individuals. Moreover, TCGA revealed T cell functions including cytolytic activity, HLA, regulation of inflammationp, co-stimulation, co-inhibition and coordination of type II INF response were significantly different between the low-risk and high-risk groups. Immune checkpoints such as PDCD-1 (PD-1), CTLA4 and LAG3, were also expressed differently between the two risk groups./nConclusion: A novel ferroptosis-related lncRNAs signature impacts on the prognosis of HNSCC.

中文翻译：

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铁死亡相关的长非编码 RNA 特征预测头颈部鳞状细胞癌的预后

背景：头颈部鳞状细胞癌（HNSCC）是头颈部癌症。另一方面，铁死亡是一种新的铁依赖性和 ROS 依赖性细胞死亡类型，观察到各种疾病状况。/n方法：我们基于 HNSCC 中与铁死亡相关的差异表达 lncRNA 构建了一个预后多 lncRNA 特征。/n结果: 我们确定了 25 种与 HNSCC 预后相关的不同表达的 lncRNA。Kaplan-Meier 分析揭示了与 HNSCC 预后不良相关的高风险 lncRNA 特征。此外，lncRNAs 特征的 AUC 为 0.782，强调了它们在预测 HNSCC 预后中的效用。事实上，我们的风险评估模型在预测 HNSCC 预后方面优于传统的临床病理学特征。GSEA 揭示了低风险人群中的免疫和肿瘤相关途径。此外，TCGA 显示 T 细胞功能包括溶细胞活性、HLA、炎症调节、共刺激、共抑制和 II 型 INF 反应的协调在低风险和高风险组之间存在显着差异。PDCD-1（PD-1）、CTLA4和LAG3等免疫检查点，结论：一种新的与铁死亡相关的 lncRNAs 特征对 HNSCC 的预后有影响。