Abstract

Objective

This study, for the first time, investigates the effect of gum acacia (GA) on the expression of miR-33 and miR-155 and its association with the obesity and inflammation induced by Western diet (WD) consumption in mice.

Methods

Animals were divided into: normal diet (ND) group, WD group, GA group and GA + WD group.

Results

The WD group exhibited higher total body, liver, visceral fat weights, blood total cholesterol, triglycerides and glucose levels compared to ND group. The liver tissues showed severe inflammation and degeneration with higher hepatic TNF-α level. Interestingly, GA + WD group showed a decrease in the biochemical parameters and hepatic TNF-α level but had no effect on the weight increase. It also showed a significant upregulation of miR-33 and miR-155 compared to WD group.

Conclusions

GA mitigated the hyperlipidaemia and inflammation but not weight increase induced by WD ingestion via upregulation of miR-33 and miR-155 while reducing TNF-α level.

中文翻译：

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阿拉伯胶上调 miR-33 和 miR-155 可减轻小鼠高脂血症和炎症，但不会减轻因西方饮食摄入引起的体重增加

摘要

客观的

本研究首次研究了阿拉伯树胶 (GA) 对小鼠 miR-33 和 miR-155 表达的影响及其与西方饮食 (WD) 诱导的肥胖和炎症的关系。

方法

动物分为：正常饮食（ND）组、WD组、GA组和GA+WD组。

结果

与ND组相比，WD组的全身、肝脏、内脏脂肪重量、血液总胆固醇、甘油三酯和葡萄糖水平更高。肝组织出现严重的炎症和变性，肝TNF-α水平较高。有趣的是，GA+WD组的生化参数和肝脏TNF-α水平有所下降，但对体重增加没有影响。与 WD 组相比，其还显示 miR-33 和 miR-155 显着上调。

结论

GA 通过上调 miR-33 和 miR-155 同时降低 TNF-α 水平，减轻了高脂血症和炎症，但没有减轻因摄入 WD 引起的体重增加。