Abstract

Silymarin is used for a wide variety of biological applications including, antidiabetic activities. However, the effectiveness of Silymarin is affected by its poor aqueous solubility and low systemic bioavailability after oral administration. The present study aimed to formulate a new, simple, and inexpensive form of silymarin solution. A new form of silymarin solution (NFSM) characterised by small particle size (227.5 nm), high entrapment efficiency (>82%), and appropriate zeta potential(–24.7mv). Moreover, the antidiabetic effects of NESM were evaluated relative to native Silymarin (SM). Oral administration of NFSM for 14 days in diabetic rats significantly decreased fasting blood glucose, oxidative stress levels, and improved lipid profile compared with SM. Also, NFSM significantly increased serum insulin levels, the gene expression of insulin and Pdx1, restored and improved the structure of the liver, and pancreas histologically. Our results concluded that NFSM may be an efficient carrier for oral delivery of silymarin for the management of diabetes and aggravated antioxidant status.

摘要

水飞蓟素用于多种生物学应用，包括抗糖尿病活动。然而，水飞蓟素的有效性受到其水溶性差和口服后全身生物利用度低的影响。本研究旨在配制一种新型、简单且廉价的水飞蓟素溶液。一种新型水飞蓟素溶液（NFSM），具有粒径小（227.5 nm）、包封率高（>82%）和合适的zeta电位（–24.7mv）等特点。此外，NESM 的抗糖尿病作用是相对于天然水飞蓟素 (SM) 进行评估的。与 SM 相比，糖尿病大鼠口服 NFSM 14 天可显着降低空腹血糖、氧化应激水平并改善血脂状况。此外，NFSM 显着增加了血清胰岛素水平，胰岛素和Pdx1的基因表达，在组织学上恢复和改善了肝脏和胰腺的结构。我们的结果得出结论，NFSM 可能是口服递送水飞蓟素的有效载体，用于治疗糖尿病和加重的抗氧化状态。