Abstract

Objective

Optical Coherence Tomography (OCT) is a relatively new diagnosis method displaying biological tissue layers by with high-resolution sections. In the present study, the purpose was to examine the OCT findings of patients with Multiple Substance Use Disorder (MSUD) by comparing these findings with healthy controls.

Methods

The study included 30 MSUD and 30 controls. Detailed biomicroscopic examinations were carried out for all participants, and intraocular pressure, followed by OCT. The central macular thickness (CMT), mean macular thickness (MMT), mean macular volume (MMV), and retinal nerve fibre layer thickness (RNFL) were measured by using OCT.

Results

It was determined that the MMT and CMT were thinned in both eyes compared to the healthy controls. The MMV was decreased in both eyes in patients with substance use disorders compared to healthy controls. The RNFL and total thickness were thickened in temporal and inferior parts in patients with MSUD in both eyes compared to healthy. In the superior quadrant, thickening was detected only in the left eye.

Conclusions

Based on our results obtained here, it was concluded that vision-related findings should be carefully questioned and evaluated when treatment is planned for patients with substance use.

中文翻译：

---

多种物质使用障碍患者的光学相干断层扫描结果

摘要

客观的

光学相干断层扫描（OCT）是一种较新的诊断方法，通过高分辨率切片显示生物组织层。在本研究中，目的是通过将这些发现与健康对照进行比较来检查多物质使用障碍 (MSUD) 患者的 OCT 发现。

方法

该研究包括 30 名 MSUD 和 30 名对照。对所有参与者进行了详细的生物显微镜检查，并进行了眼压检查，然后进行了 OCT。使用OCT测量中央黄斑厚度（CMT）、平均黄斑厚度（MMT）、平均黄斑体积（MMV）和视网膜神经纤维层厚度（RNFL）。

结果

确定与健康对照相比，双眼的 MMT 和 CMT 变薄。与健康对照组相比，物质使用障碍患者双眼的 MMV 降低。与健康人相比，双眼MSUD患者颞下部的RNFL和总厚度增厚。在上象限，仅在左眼中检测到增厚。

结论

根据我们在此获得的结果，得出的结论是，在计划对物质使用患者进行治疗时，应仔细质疑和评估与视力相关的发现。