ABSTRACT

Depression symptoms are known to influence gait speed in cognitively healthy adults. In this study, we aimed to examine the relationship between gait speed and depression symptoms in older patients with mild cognitive impairment. The participants were classified as slow and normal gait speed based on the Fried criteria. A total of 152 subjects with mild cognitive impairment were included. Of these, 39.5% (n=60) had slow gait speed. Compared to normal speed group (n=92), patients with slow speed had more clinically significant depression (geriatric depression scale score ≥ 6) (p=0.004), cardiovascular disease (p=0.007), recent falls (p<0.001), and anticholinergic burden (p=0.005). Multivariable logistic regression analysis yielded statistically significant associations between slow gait speed and depression in age and gender adjusted [OR:3.30 (1.46-7.46), p=0.004] and fully adjusted [OR: 2.80 (1.10-7.08), p=0.030] models. This study showed an independent association between slow gait speed and depression symptoms in older people with mild cognitive impairment.

摘要

众所周知，抑郁症状会影响认知健康成年人的步态速度。在这项研究中，我们旨在检查老年轻度认知障碍患者的步态速度与抑郁症状之间的关系。根据 Fried 标准，参与者被分为慢步态和正常步态。共纳入 152 名轻度认知障碍受试者。其中，39.5% (n=60) 的步态速度较慢。与正常速度组 (n=92) 相比，速度较慢的患者出现临床上显着的抑郁症（老年抑郁量表评分 ≥ 6）（p=0.004）、心血管疾病（p=0.007）、近期跌倒（p<0.001）、和抗胆碱能负担 (p=0.005)。多变量逻辑回归分析显示，慢步态速度与年龄和性别调整后的抑郁症之间存在统计学显着关联 [OR:3.30 (1. 46-7.46), p=0.004] 和完全调整的 [OR: 2.80 (1.10-7.08), p=0.030] 模型。这项研究表明，在患有轻度认知障碍的老年人中，缓慢的步态速度与抑郁症状之间存在独立关联。