ABSTRACT

We aimed to evaluate 14 urinary phthalate metabolites and 4 toxic metals in adolescents having thyroid colloid cyst (TCC) and compare with age and sex-matched others without TCC. Phthalate metabolites were analysed with UPLC-MS/MS and heavy metals with ICP-MS. TCC ratios in tertile subgroups of pollutants were compared with multiple logistic regression analysis after adjusting for age, sex, z-scores for body mass index and urinary creatinine values. Adolescents having the highest tertile of mono (2-ethylhexyl) phthalic acid and mercury had increased odds and those with the highest tertiles of monocarboxy-isononyl phthalate, mono (3-carboxypropyl) phthalate, monoisobutyl phthalate had lower odds for TCC than counterparts. The odds of TCC were lower for those in the second and the third tertiles. No differences in TCC ratios were detected with other pollutants. Given phthalate esters’ and toxic metals’ specific interactions on TCC, further studies were necessary to assess the influence of chemicals on TCC.

摘要

我们旨在评估患有甲状腺胶体囊肿 (TCC) 的青少年的 14 种尿邻苯二甲酸盐代谢物和 4 种有毒金属，并与年龄和性别匹配的未患有 TCC 的其他人进行比较。使用 UPLC-MS/MS 分析邻苯二甲酸盐代谢物，使用 ICP-MS 分析重金属。在调整年龄、性别、体重指数的 z 值和尿肌酐值后，将三分位数污染物亚组中的 TCC 比率与多元逻辑回归分析进行比较。具有最高三分位数的单（2-乙基己基）邻苯二甲酸和汞的青少年患 TCC 的几率增加，而那些具有最高三分位数的邻苯二甲酸单羧基异壬酯、邻苯二甲酸单（3-羧丙基）酯、邻苯二甲酸单异丁酯的几率比同龄人低。第二和第三个三分位数的人发生 TCC 的几率较低。与其他污染物相比，TCC 比率没有差异。鉴于邻苯二甲酸酯和有毒金属对 TCC 的特定相互作用，需要进一步研究来评估化学品对 TCC 的影响。