Abstract

Bacterial biofilms play a role in a majority of chronic infections. Such infections are the result of bacterial colonization and matrix construction, which yield protective structures that are much more difficult to treat than planktonic (free-floating), acute infections. Because of the medical challenges that biofilm infections impose, technological advancements and innovation for diagnosis, characterization, and treatment are greatly needed. One technology which has been increasingly recognized for its potential in biofilm characterization is Fourier transform infrared (FTIR) spectroscopy. As such, the aim of this review is to discuss the state of FTIR research in its application to medical microbiology and to offer insight into its prospective adoption by healthcare providers.

摘要

细菌生物膜在大多数慢性感染中起作用。这种感染是细菌定植和基质构建的结果，它们产生的保护结构比浮游（自由漂浮）的急性感染更难治疗。由于生物膜感染带来的医学挑战，非常需要用于诊断、表征和治疗的技术进步和创新。傅里叶变换红外 (FTIR) 光谱法是一项因其在生物膜表征方面的潜力而日益得到认可的技术。因此，本综述的目的是讨论 FTIR 研究在其在医学微生物学中的应用情况，并提供有关医疗保健提供者对其未来采用的见解。