Mitochondria‐associated endoplasmic reticulum membranes: At the crossroad between familiar and sporadic Alzheimer's disease,SYNAPSE

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Mitochondria‐associated endoplasmic reticulum membranes: At the crossroad between familiar and sporadic Alzheimer's disease
SYNAPSE ( IF 1.6 ) Pub Date : 2021-02-09 , DOI: 10.1002/syn.22196
Kangrun Wang ₁ , Wenling Zhang ₂

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Alzheimer's disease (AD) is the leading cause of dementia and is incurable. The widely accepted amyloid hypothesis failed to produce efficient clinical therapies. In contrast, there is increasing evidence suggesting that the disruption of mitochondria‐associated endoplasmic reticulum (ER) membranes (MAM) is a critical upstream event of AD pathogenesis. Here, we review MAM's role in some AD symptoms such as plaque formation, tau hyperphosphorylation, synaptic loss, aberrant lipid synthesis, disturbed calcium homeostasis, and abnormal autophagy. At last, we proposed that MAM plays a central role in familial AD (FAD) and sporadic AD (SAD).

中文翻译：

线粒体相关内质网膜：处于熟悉和散发阿尔茨海默病之间的十字路口

阿尔茨海默病 (AD) 是痴呆症的主要原因，并且无法治愈。广泛接受的淀粉样蛋白假说未能产生有效的临床疗法。相比之下，越来越多的证据表明线粒体相关内质网 (ER) 膜 (MAM) 的破坏是 AD 发病机制的关键上游事件。在这里，我们回顾了 MAM 在一些 AD 症状中的作用，例如斑块形成、tau 过度磷酸化、突触丢失、脂质合成异常、钙稳态紊乱和自噬异常。最后，我们提出 MAM 在家族性 AD (FAD) 和散发性 AD (SAD) 中起核心作用。

更新日期：2021-04-04

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