The aim of this study was to investigate the relationship between different estrus synchronization protocols, some fertility parameters and serum biochemical parameters including total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), thyroid stimulating hormone (TSH), estradiol (E₂) and progesterone (P₄) in Hair goats. The study was carried out on 150 female Hair goats during the breeding season. Goats were divided into three groups as control (n = 50), short-term (n = 50) and long-term (n = 50) groups. Control group did not receive any treatment, short-term group received intravaginal P₄ (7 d) combined with GnRH (on days 0 and 9) and PGF2α (on day 7), and long-term group received intravaginal P₄ (12 d) combined with pregnant mare's serum gonadotropin (on day 12) and GnRH (on day 13). In control group, blood samples were collected at the beginning (first measurement) and 7th day (second measurement) of the study. In short-term and long-term groups, blood samples were collected at the time of sponge insertion (first measurement) and withdrawal (second measurement). Serum TAS, TOS, P₄, E₂, TSH levels were measured on all sampling days, and OSI was calculated. All the groups were observed for estrus behavior and those showing the signs of estrus were allowed for mating. Transrectal ultrasound examination was performed to diagnose pregnancy approximately 40 days after mating. The onset of estrus was earlier in short-term group compared to long-term group (P < 0.001). The estrus and pregnancy rates were significantly higher in short-term group compared to other groups (P < 0.05). At the time of first measurement, E₂ level in short-term group and P₄ level in long-term group were higher and lower than the other groups, respectively (P < 0.05). At the time of second measurement, TAS, TOS, OSI and E₂ levels were significantly different in short-term group compared to control and long-term groups (P < 0.01). Additionally, P₄ level in control group and TSH level in long-term group increased (P < 0.01). While TAS level in short-term group and E₂ level in all groups increased from the first measurement to the second measurement, the TOS and OSI values decreased (P < 0.01). TSH level in short-term group decreased from the first measurement to the second measurement (P < 0.01), while it increased in long-term and control groups (P < 0.05). In conclusion, it was obtained that synchronization protocols can affect serum TAS, TOS, E₂, P₄, TSH and OSI levels; and short-term intravaginal P₄ treatment combined with GnRH and PGF2α clearly improved the antioxidant defense system and increased fertility parameters in Hair goats.

这项研究的目的是调查不同的发情同步协议，一些生育参数和血清生化参数之间的关系，包括总抗氧化剂状态（TAS），总氧化剂状态（TOS），氧化应激指数（OSI），甲状腺刺激激素（TSH） ），毛山羊中的雌二醇（E ₂）和孕酮（P ₄）。该研究是在繁殖季节对150只雌性毛山羊进行的。将山羊分为三组，分别为对照组（n = 50），短期（n = 50）和长期（n = 50）。对照组未接受任何治疗，短期组接受了阴道内P ₄（7 d）联合GnRH（在第0和9天）和PGF2α（在第7天），长期组接受阴道内P ₄（12 d）联合孕妇母马的血清促性腺激素（在第12天）和GnRH（在第12天）第13天）。在对照组中，在研究的开始（第一次测量）和第七天（第二次测量）收集血液样本。在短期和长期组中，在插入海绵（第一次测量）和抽取海绵（第二次测量）时收集血液样本。血清TAS，TOS，P ₄，E ₂，在所有采样日测量TSH水平，并计算OSI。观察所有组的发情行为，并且将显示发情迹象的组交配。交配后约40天进行经直肠超声检查以诊断妊娠。与长期组相比，短期组的发情发作更早（P <0.001）。短期组的发情和妊娠率显着高于其他组（P <0.05）。初次测量时，短期组的E ₂水平和长期组的P ₄水平分别高于和低于其他组（P<0.05）。在第二次测量时，短期组的TAS，TOS，OSI和E ₂水平与对照组和长期组相比有显着差异（P <0.01）。另外，对照组的P ₄水平和长期组的TSH水平升高（P <0.01）。从第一次测量到第二次测量，短期组的TAS水平和所有组的E _2水平均升高，但TOS和OSI值却降低了（P <0.01）。短期组的TSH水平从第一次测量降低到第二次测量（P <0.01），而长期和对照组的TSH水平则升高（P<0.05）。总之，已获得同步方案可影响血清TAS，TOS，E ₂，P ₄，TSH和OSI水平。短期阴道内P ₄处理与GnRH和PGF2α的结合明显改善了毛山羊的抗氧化防御系统并提高了生育力参数。