The development of nanoscale thermal sensors with high sensitivity to ambient temperature change is crucial to monitor the biological processes from living forms. In this work, we report on the Nd³⁺-doped Bi₂SiO₅ nanospheres acting as nanothermometers in the first biological window. Uniform Bi₂SiO₅:Nd³⁺ nanospheres are synthesized by the diffusion and reaction between the bismuth-based precursor core and the silica shell. The as-synthesized Bi₂SiO₅:Nd³⁺ nanospheres can be effectively excited by 808 nm near infrared laser diode and emit in the near infrared range due to the characteristic transitions of Nd³⁺. The luminescence intensity ratio of two spectrally separated emission peaks located at 867 nm (P1) and 898 nm (P2) from the ⁴F_3/2 → ⁴I_9/2 transition of Nd³⁺ is found to be noticeably temperature-dependent, which can be used for luminescent ratiometric thermal sensing. The results reveal that the yielded Bi₂SiO₅:Nd³⁺ nanothermometers possess suitable values of relative sensitivity, temperature uncertainty and repeatability within the physiologically relevant temperature range. These Nd³⁺-doped Bi₂SiO₅ nanospheres emerge as very promising temperature probes for luminescence nanothermometry.

对环境温度变化具有高灵敏度的纳米级热传感器的开发对于监控生物形式的生物过程至关重要。在这项工作中，我们报道了在第一个生物窗口中充当纳米温度计的Nd ³⁺掺杂的Bi ₂ SiO ₅纳米球。通过铋基前驱体核与二氧化硅壳之间的扩散和反应，合成出均匀的Bi ₂ SiO ₅：Nd ³⁺纳米球。合成后的Bi ₂ SiO ₅：Nd ³⁺纳米球可以被808 nm近红外激光二极管有效激发，并由于Nd的特征跃迁而在近红外范围内发射。³⁺。发现从Nd ³⁺的⁴ F _3/2  →  ⁴ I _9/2跃迁位于867 nm（P1）和898 nm（P2）处的两个光谱分离的发射峰的发光强度比明显取决于温度，可用于发光比例热感测。结果表明，所产生的Bi ₂ SiO ₅：Nd ³⁺纳米温度计在生理相关温度范围内具有相对灵敏度，温度不确定性和重复性的合适值。这些掺Nd ^3+的Bi ₂ SiO ₅ 纳米球作为发光纳米温度计的非常有前途的温度探针出现。