The immune system actively regulates brain activity through the engagement of immune cells and immunomodulatory molecules. In this issue of Immunity, Klawonn et al. show that the activation of microglia in the striatum triggers an IL-6-mediated autocrine loop and the release of prostaglandins, which in turn induce a negative affective state via the stimulation of medium spiny neurons.

中文翻译：

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情绪低落？保持冷静，观察小胶质细胞

免疫系统通过免疫细胞和免疫调节分子的参与来主动调节大脑活动。在本期《免疫》中，Klawonn 等人。表明纹状体中小胶质细胞的激活触发了 IL-6 介导的自分泌环和前列腺素的释放，这反过来又通过刺激中等多刺神经元诱导了负面情感状态。