Objective

Several risk factors for type 2 diabetes mellitus (T2DM) are also associated with blood concentrations of persistent organic pollutants (POPs), and factors related to the disease may affect POP concentrations, and subsequent associations between POPs and T2DM. The purpose of this pilot study was to investigate the change in concentrations of lipids, hormones and POPs pre- and post-diagnosis in T2DM cases compared to healthy controls and their associations with T2DM.

Methods

We measured POPs, lipids, and thyroid and steroid hormones in plasma from 44 female cases collected prior to (pre-diagnostic) and following (post-diagnostic) T2DM diagnosis, and in 44 healthy female age-matched controls. We compared cross-sectional differences and longitudinal changes within and between matched cases and controls with t-tests and multivariable linear regression models. Associations between POP concentrations and T2DM were investigated using conditional logistic regression.

Results

Between the pre- and post-diagnostic measurement, cases developed more favorable lipid profiles and the longitudinal changes in lipid-normalized concentrations of non-dioxin-like polychlorinated biphenyls (PCBs), dioxin-like PCBs, beta-hexachlorocyclohexane (HCH), HCB, and 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (p,p'-DDE) differed significantly between cases and controls. The longitudinal changes in POPs were mainly driven by changes in bodyweight, total lipids and T2DM status. Cases had significantly higher pre-diagnostic concentrations of POPs and triglycerides, and lower concentrations of high-density lipoprotein cholesterol and free thyroxin than controls. Pre-diagnostic POP concentrations were not significantly associated with incident T2DM, whereas several post-diagnostic POP concentrations were significantly positively associated with prevalent T2DM.

Conclusions

This pilot study suggests that factors related to T2DM affect blood concentrations of POPs and may partly explain the positive associations between POPs and T2DM.

中文翻译：

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在2型糖尿病病例和对照中，对氯化持久性有机污染物和代谢标记物进行诊断前和诊断后的血液状况；初步研究

客观的

2型糖尿病（T2DM）的几种风险因素也与持久性有机污染物（POPs）的血药浓度相关，与疾病相关的因素可能会影响POP浓度，以及POPs与T2DM之间的关联。这项初步研究的目的是调查与健康对照及其与T2DM的关联相比，T2DM病例在诊断前后的血脂，激素和POPs浓度变化。

方法

我们在T2DM诊断之前（诊断前）和诊断之后（诊断后），以及44位年龄匹配的健康女性对照中，测量了44例女性病例血浆中的POPs，脂质以及甲状腺和类固醇激素。我们使用t检验和多变量线性回归模型比较了匹配病例和对照之间以及对照之间的横截面差异和纵向变化。使用条件逻辑回归研究了POP浓度与T2DM之间的关联。

结果

在诊断之前和之后的测量之间，病例表现出更有利的脂质分布，并且脂质标准化浓度的非二恶英样多氯联苯（PCBs），二恶英样PCBs，β-六氯环己烷（HCH），HCB呈纵向变化和1,1,1-三氯-2,2-双（4-氯苯基）乙烷（p，p'-DDE）在病例与对照组之间存在显着差异。POPs的纵向变化主要是由体重，总脂质和T2DM状态的变化驱动的。与对照组相比，患者的POPs和甘油三酸酯的诊断前浓度明显较高，而高密度脂蛋白胆固醇和游离甲状腺素的浓度较低。诊断前的POP浓度与T2DM发病率无显着相关性，

结论

这项初步研究表明，与T2DM相关的因素会影响POPs的血药浓度，并可能部分解释POPs与T2DM之间的正相关。