To assess the clinicopathological features, prognostic factors, and survival rates associated with uterine leiomyosarcoma (uLMS). Databases from 15 participating gynecological oncology centers in Turkey were searched retrospectively for women who had been treated for stage I-IV uLMS between 1996 and 2018. Of 302 consecutive women with uLMS, there were 234 patients with Federation of Gynecology and Obstetrics (FIGO) stage I disease and 68 with FIGO stage II-IV disease. All patients underwent total hysterectomy. Lymphadenectomy was performed in 161 (54.5%) cases. A total of 195 patients received adjuvant treatment. The 5-year disease-free survival (DFS) and overall survival (OS) rates were 42% and 54%, respectively. Presence of lymphovascular space invasion (LVSI), higher degree of nuclear atypia, and absence of lymphadenectomy were negatively correlated with DFS, while LVSI, mitotic count, higher degree of nuclear atypia, FIGO stage II-IV disease, and suboptimal surgery significantly decreased OS. LVSI and higher degree of nuclear atypia appear to be prognostic indicators for uLMS. Lymphadenectomy seems to have a significant effect on DFS but not on OS.

评估与子宫平滑肌肉瘤 (uLMS) 相关的临床病理学特征、预后因素和存活率。对来自土耳其 15 个参与的妇科肿瘤中心的数据库进行了回顾性搜索，以查找在 1996 年至 2018 年期间接受过 I-IV 期 uLMS 治疗的女性。在 302 名连续患有 uLMS 的女性中，有 234 名患者处于妇产科联合会 (FIGO) 阶段I 病和FIGO II-IV 期疾病68 人。所有患者均行全子宫切除术。161 例 (54.5%) 病例进行了淋巴结切除术。共有195名患者接受了辅助治疗。5 年无病生存 (DFS) 和总生存 (OS) 率分别为 42% 和 54%。存在淋巴血管间隙浸润（LVSI），核异型程度较高，无淋巴结清扫与 DFS 呈负相关，而 LVSI、有丝分裂计数、较高程度的核异型性、FIGO II-IV 期疾病和次优手术显着降低 OS。LVSI 和更高程度的核异型性似乎是 uLMS 的预后指标。淋巴结切除术似乎对 DFS 有显着影响，但对 OS 没有影响。