New diseases are emerging as the environment changes, so drug manufacturers are always on the lookout for new resources to develop effective and safe drugs. In recent years, many bioactive substances have been produced in the marine environment, which represents an alternative resource for new drugs used to combat major diseases such as cancer or inflammation. Many marine-derived medicinal substances are in preclinical or early stage of clinical development, and some marine drugs have been put on the market, such as ET743 (Yondelis®). This review presents the sources, activities, mechanisms of action and syntheses of bioactive substances based on marine natural products in clinical trials and on the market, which is helpful to understand the progress of drug research by application of marine natural products.

随着环境的变化，新的疾病不断出现，因此药物制造商一直在寻找新的资源来开发有效和安全的药物。近年来，海洋环境中产生了许多生物活性物质，这代表了用于对抗癌症或炎症等重大疾病的新药的替代资源。许多海洋来源的药用物质处于临床前或临床开发的早期阶段，一些海洋药物已经上市，如ET743（Yondelis®）。本文综述了基于海洋天然产物在临床试验和上市中的生物活性物质的来源、活性、作用机制和合成，有助于了解海洋天然产物应用的药物研究进展。