MicroRNA (miR) acts as a negative regulator of gene expression. Many literatures have suggested that miRs may be involved in the process of cell proliferation, inflammation, oxidative stress, energy metabolism and epithelial mesenchymal transition. Thus, miRs may be implicated in the occurrence of non-small cell lung cancer (NSCLC). In the current investigation, we included 2,249 subjects (1,193 NSCLC patients and 1,056 controls) and designed a study to identify the relationship of miR-146a rs2910164 C/G, -499a rs3746444 A/G, and -196a-2 rs11614913 T/C with the risk of NSCLC. The risk factors (e.g., body mass index, sex, smoking, drinking and age), was used to adjust the odds ratios and 95% confidence intervals. After conducting a power value assessment, we did not confirm that the miR-SNPs genotypic distributions were different in NSCLC cases and controls. However, the association of miR-196a-2 rs11614913 with a decrease risk of NSCLC was identified in the female subgroup (adjusted P=0.005, power=0.809 for TC vs. TT, and adjusted P=0.004, power=0.849 for CC/TC vs. TT). In addition, gene-gene interaction analysis showed that rs11614913 TC/3746444 AA and rs11614913 CC/rs3746444 AA could also reduce the susceptibility to NSCLC (rs11614913 TC/rs3746444 AA vs. rs11614913 TT/rs3746444 AA, P=0.001, power=0.912 and rs11614913 CC/rs3746444 AA vs. rs11614913 TT/rs3746444 AA, P=0.003, power=0.836). In conclusion, in overall comparisons, we did not confirm that the rs2910164, rs3746444, and rs11614913 SNPs genotypic distributions were different in NSCLC cases and controls. However, this case-control study demonstrates that miR-196a-2 rs11614913 may be a protective factor for the development of NSCLC among female patients.

中文翻译：

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microRNA-146a、-499a 和-196a-2 SNP 与非小细胞肺癌之间的关联：一项涉及 2,249 名受试者的病例对照研究。

MicroRNA (miR) 作为基因表达的负调节因子。许多文献表明miRs可能参与细胞增殖、炎症、氧化应激、能量代谢和上皮间质转化过程。因此，miR可能与非小细胞肺癌（NSCLC）的发生有关。在目前的调查中，我们纳入了 2,249 名受试者（1,193 名 NSCLC 患者和 1,056 名对照）并设计了一项研究来确定 miR-146a rs2910164 C/G、-499a rs3746444 A/G 和 -196a-2 rs11614913 之间的关系与非小细胞肺癌的风险。风险因素（例如，体重指数、性别、吸烟、饮酒和年龄）用于调整优势比和 95% 置信区间。进行功率值评估后，我们没有证实 NSCLC 病例和对照中的 miR-SNP 基因型分布不同。然而，在女性亚组中确定了 miR-196a-2 rs11614913 与 NSCLC 风险降低的关联（调整 P=0.005，TC vs. TT 的调整 P=0.005，功效=0.809，调整 P=0.004，CC/ TC 与 TT）。此外，基因-基因相互作用分析表明，rs11614913 TC/3746444 AA 和 rs11614913 CC/rs3746444 AA 也可以降低对 NSCLC 的易感性（rs11614913 TC/rs3746444 AA vs. rs130444 AA vs. rs13047rs,4404 AA 和 rs130416 = 4404 AA = 4 rs11614913 CC/rs3746444 AA 与 rs11614913 TT/rs3746444 AA，P=0.003，功率=0.836）。总之，在总体比较中，我们没有证实 rs2910164、rs3746444 和 rs11614913 SNP 基因型分布在 NSCLC 病例和对照中存在差异。然而，