ABSTRACT Mini Mental State Examination (MMSE) has been used as a tool to detect cognitive impairment in patients treated with antiepileptic drugs, however fail to detect mild cognitive impairment in these patients. Studies report Montreal Cognitive Assessment (MOCA) is more sensitive than MMSE in detecting cognitive status in patients with stroke, parkinsonism, cardiovascular disease and epilepsy. Homocysteine has been implicated in the modulation of cognitive impairment in epilepsy but could not be established clearly as most studies followed MMSE. To investigate the relationship between homocysteine and cognitive status the present study employed MOCA in comparison with MMSE in epilepsy population with phenytoin monotherapy. Our findings suggest MOCA is more sensitive than MMSE in demonstrating the relationship between homocysteine and cognitive impairment in epilepsy.

中文翻译：

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苯妥英单药治疗癫痫患者同型半胱氨酸与认知状态之间的关联的蒙特利尔认知评估（MOCA）与迷你精神状态检查（MMSE）的比较

摘要迷你精神状态检查（MMSE）已被用作检测使用抗癫痫药物治疗的患者的认知障碍的工具，但是未能检测到这些患者的轻度认知障碍。研究报告蒙特利尔认知评估（MOCA）在检测中风，帕金森病，心血管疾病和癫痫患者的认知状态方面比MMSE敏感。同型半胱氨酸与癫痫认知障碍的调节有关，但由于大多数研究都遵循MMSE，因此尚不能明确确定。为了研究高半胱氨酸与认知状态之间的关系，本研究采用苯妥英单药治疗癫痫人群中的MOCA和MMSE进行比较。