Synergetic catalysis of Se and Cu allowing diethoxylation of halomethylene ketones using O2 as the mild oxidant,Reaction Chemistry & Engineering

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Synergetic catalysis of Se and Cu allowing diethoxylation of halomethylene ketones using O2 as the mild oxidant
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2021-1-26 , DOI: 10.1039/d0re00471e
Zhicheng Cao _{1,

2,

3,

4,

5} , Xin Deng _{1,

2,

3,

4} , Chao Chen _{1,

2,

3,

4} , Yonghong Liu _{1,

2,

3,

4} , Lei Yu _{1,

2,

3,

4} , Xuefeng Jiang _{4,

5,

6,

7,

8}

Affiliation

PhSe(O)OH/Cu(OAc)₂-Catalyzed diethoxylation of halomethylene ketones for the construction of useful α-keto acetals was developed. Synergetic catalysis of Se and Cu allowed the utilization of molecular oxygen as a safe oxidant instead of explosive hydrogen peroxide. The easily accessible bromo-containing substrates could release HBr during the reaction, which promoted the key enol intermediate to avoid the use of acidic additives and allow the reaction to occur under mild conditions.

中文翻译：

硒和铜的协同催化，使用O2作为温和氧化剂，可实现卤代亚甲基酮的二乙氧基化

开发了PhSe（O）OH / Cu（OAc）_2-卤代亚甲基酮的二乙氧基化反应，以构建有用的α-酮缩醛。硒和铜的协同催化作用使分子氧可以用作安全的氧化剂，而不是爆炸性的过氧化氢。易于接触的含溴底物可以在反应过程中释放HBr，从而促进了关键的烯醇中间体的使用，从而避免了使用酸性添加剂，并使反应在温和的条件下发生。

更新日期：2021-02-08

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