Immediately following the discovery of the structure of DNA and the semi-conservative replication of the parental DNA sequence into two new DNA strands, it became apparent that DNA replication is organized in a temporal and spatial fashion during the S phase of the cell cycle, correlated with the large-scale organization of chromatin in the nucleus. After many decades of limited progress, technological advances in genomics, genome engineering, and imaging have finally positioned the field to tackle mechanisms underpinning the temporal and spatial regulation of DNA replication and the causal relationships between DNA replication and other features of large-scale chromosome structure and function. In this review, we discuss these major recent discoveries as well as expectations for the coming decade.

中文翻译：

---

哺乳动物 DNA 复制时间


紧接着发现 DNA 结构和亲本 DNA 序列半保守复制成两条新 DNA 链后，很明显 DNA 复制在细胞周期的 S 期以时间和空间方式组织，相关与细胞核中染色质的大规模组织有关。经过数十年的有限进展，基因组学、基因组工程和成像技术的进步最终使该领域能够解决支撑 DNA 复制的时间和空间调控的机制，以及 DNA 复制与大规模染色体结构其他特征之间的因果关系。和功能。在这篇评论中，我们讨论了这些最近的重大发现以及对未来十年的期望。