We examined the relative contribution of pulmonary diseases (chronic obstructive pulmonary disease, asthma and sleep apnea) to mortality risks associated with Coronavirus Disease (COVID-19) independent of other medical conditions, health risks, and sociodemographic factors. Data were derived from a large US-based case series of patients with COVID-19, captured from a quaternary academic health network covering New York City and Long Island. From March 2 to May 24, 2020, 11,512 patients who were hospitalized were tested for COVID-19, with 4,446 (38.62%) receiving a positive diagnosis for COVID-19. Among those who tested positive, 959 (21.57%) died of COVID-19-related complications at the hospital. Multivariate-adjusted Cox proportional hazards modeling showed mortality risks were strongly associated with greater age (HR = 1.05; 95% CI: 1.04–1.05), ethnic minority (Asians, Non-Hispanic blacks, and Hispanics) (HR = 1.26; 95% CI, 1.10–1.44), low household income (HR = 1.29; 95% CI: 1.11, 1.49), and male sex (HR = 0.85; 95% CI: 0.74, 0.97). Higher mortality risks were also associated with a history of COPD (HR = 1.27; 95% CI: 1.02–1.58), obesity (HR = 1.19; 95% CI: 1.04–1.37), and peripheral artery disease (HR = 1.33; 95% CI: 1.05–1.69). Findings indicate patients with COPD had the highest odds of COVID-19 mortality compared with patients with pre-existing metabolic conditions, such as obesity, diabetes and hypertension. Sociodemographic factors including increased age, male sex, low household income, ethnic minority status were also independently associated with greater mortality risks.

我们研究了肺部疾病（慢性阻塞性肺病、哮喘和睡眠呼吸暂停）对冠状病毒病（COVID-19）相关死亡风险的相对影响，独立于其他医疗状况、健康风险和社会人口因素。数据源自美国的一个大型 COVID-19 患者病例系列，这些病例是从覆盖纽约市和长岛的第四纪学术健康网络获取的。 2020年3月2日至5月24日，对11,512名住院患者进行了COVID-19检测，其中4,446人（38.62%）的COVID-19诊断呈阳性。在检测结果呈阳性的人中，有 959 人（21.57%）在医院死于与 COVID-19 相关的并发症。多变量调整 Cox 比例风险模型显示，死亡风险与较大年龄（HR = 1.05；95% CI：1.04–1.05）、少数族裔（亚洲人、非西班牙裔黑人和西班牙裔）（HR = 1.26；95%）密切相关。 CI，1.10-1.44）、低家庭收入（HR = 1.29；95% CI：1.11，1.49）和男性（HR = 0.85；95% CI：0.74，0.97）。较高的死亡风险还与慢性阻塞性肺病（HR = 1.27；95% CI：1.02–1.58）、肥胖（HR = 1.19；95% CI：1.04–1.37）和外周动脉疾病（HR = 1.33；95）病史相关。 % CI：1.05–1.69）。研究结果表明，与已有代谢疾病（如肥胖、糖尿病和高血压）的患者相比，慢性阻塞性肺病（COPD）患者的 COVID-19 死亡率最高。社会人口因素，包括年龄增长、男性、家庭收入低、少数民族身份也与较高的死亡风险独立相关。