Background. Both non-suicidal self-injuries (NSSIs) and suicidal attempts (SAs) in adolescence represent significant risk factors for consequent suicide, but neurophysiological markers and predictors of these two forms of auto-aggressive behavior have been studied insufficiently. Objective. The aim of the study was to identify the differences of electroencephalographic (EEG) frequency and spatial parameters between depressive female adolescents with solely NSSI, and with combined NSSI + SA behavior in their history. Methods. The study included 45 female depressive in-patients aged 16-25 years. Baseline resting EEG spectral power, asymmetry, and coherence were analyzed in 8 narrow frequency sub-bands. Results. In the NSSI + SA subgroup (n = 24), the spectral power of parietal–occipital alpha-2 (9-11 Hz) was higher than in the NSSI subgroup, its focus was localized in the right hemisphere, and alpha-3 (11-13 Hz) spectral power was higher than alpha-1 (8-9 Hz). In the NSSI subgroup (n = 21) alpha-1 spectral power was higher than alpha-3, and foci of alpha-2 and alpha-3 were localized in the left hemisphere. EEG coherence was also higher in the NSSI + SA subgroup than in the NSSI subgroup, especially in frontal–central–parietal regions. Conclusions. The spatial distribution of the EEG frequency components in the NSSI + SA subgroup reflects the greater activation of the left hemisphere that is more typical for the EEG of individuals with an increased risk for suicide. In the NSSI subgroup, the right hemisphere is relatively more activated, and EEG coherence is lower, which is more typical for EEG in depressive disorders. The results obtained suggested the use of EEG to clarify the degree of suicidal risk in depressive female adolescents with NSSI.

背景。青春期的非自杀性自伤 (NSSI) 和自杀未遂 (SA) 都是随后自杀的重要危险因素，但这两种形式的自我攻击行为的神经生理学标志物和预测因子尚未得到充分研究。客观的。该研究的目的是确定仅患有 NSSI 的抑郁女性青少年和其历史上合并 NSSI + SA 行为的抑郁女性青少年之间的脑电图 (EEG) 频率和空间参数的差异。方法。该研究包括 45 名年龄在 16-25 岁之间的女性抑郁症住院患者。在 8 个窄子频带中分析了基线静息 EEG 频谱功率、不对称性和相干性。结果。在 NSSI + SA 亚组 (n = 24) 中，顶枕叶 alpha-2 (9-11 Hz) 的频谱功率高于 NSSI 亚组，其焦点位于右半球，而 alpha-3 ( 11-13 Hz) 频谱功率高于 alpha-1 (8-9 Hz)。在 NSSI 亚组 (n = 21) 中，alpha-1 光谱功率高于 alpha-3，并且 alpha-2 和 alpha-3 的焦点位于左半球。NSSI + SA 亚组的 EEG 一致性也高于 NSSI 亚组，尤其是在额叶-中央-顶叶区域。结论。NSSI + SA 亚组中 EEG 频率分量的空间分布反映了左半球的更大激活，这对于自杀风险增加的个体的 EEG 来说更为典型。在NSSI亚组中，右半球相对更活跃，脑电相干性较低，这在抑郁症脑电图上更为典型。获得的结果表明使用脑电图来阐明患有 NSSI 的抑郁女性青少年的自杀风险程度。