Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp.,Journal of Natural Products

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Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2021-02-08 , DOI: 10.1021/acs.jnatprod.0c01243
Xi Xie ₁ , Shengsheng Lu ₁ , Xiaoyan Pan ₂ , Min Zou ₁ , Fangfang Li ₃ , Haixing Lin ₁ , Jianan Hu ₁ , Sheng Fan ₁ , Jian He ₁

Affiliation

A new bafilomycin derivative (1) and another seven known bafilomycins (2–8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC₅₀ values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.

中文翻译：

粪便中链霉菌sp。的抗病毒Bafilomycins 。

一个新的巴弗洛霉素衍生物（1）和另外七已知巴弗洛霉素（2 - 8）从粪便来源的分离的链霉菌属。HTL16。通过1D和2D NMR光谱分析阐明了1的结构。生物学测试表明，这些bafilomycins通过抑制内体ATP驱动的质子泵的活性，对甲型流感病毒和SARS-CoV-2病毒表现出有效的抗病毒活性，IC ₅₀值在纳摩尔范围内。

更新日期：2021-02-26

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