The dielectric constant of the normal corneal tissue of a rabbit eye was obtained in vitro in the range from approximately 0.1 to 1 THz, and the drying process on the eye surface exposed to high-power terahertz waves was investigated by in vivo reflectance measurement using terahertz time-domain spectroscopy. When the rabbit eye was exposed to terahertz waves at 162 GHz for 6 min with an irradiation power of 360 or 480 mW/cm², the reflectance temporally increased and then decreased with a temperature increase. Based on multiple-reflection calculation using the dielectric constant and anterior segment optical coherence tomography images, those changes in reflectance were attributed to drying of the tear and epithelium of the cornea, respectively. Furthermore, the drying progressed over a temperature increase of around 5°C under our exposure conditions. These findings suggest that the possibility of eye damage increases with the progress of drying and that the setting of the eye surface conditions can be a cause of disagreement between computational and experimental data of absorbed energy under high-level irradiation because reflectance is related to terahertz wave penetration in the eye tissue. The time-domain spectroscopic measurements were useful for the acquisition of the dielectric constant as well as for the real-time monitoring of the eye conditions during exposure measurement.

中文翻译：

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太赫兹带体内和体外计算眼用剂量法测定角膜组织的介电性能

体外在约0.1至1 THz的范围内获得了兔眼正常角膜组织的介电常数，并通过使用太赫兹的体内反射率测量研究了暴露于大功率太赫兹波的眼睛表面的干燥过程时域光谱。当兔眼在162 GHz的太赫兹波下以360或480 mW / cm ²的照射功率暴露6分钟时，反射率随温度的升高先升高后降低。基于使用介电常数和前段光学相干断层扫描图像进行的多次反射计算，反射率的变化分别归因于眼角膜的泪液和角膜上皮干燥。此外，在我们的暴露条件下，干燥过程在温度升高约5°C时进行。这些发现表明，眼睛干燥的可能性随着干燥的进行而增加，并且眼睛表面条件的设置可能是导致高能照射下吸收能量的计算数据和实验数据不一致的原因，因为反射率与太赫兹波有关渗透到眼组织中。