Abstract

The number of optical coherence tomography (OCT) examinations in substance use disorders is gradually increasing. However, OCT findings in opioid use disorder (OUD) have not yet been investigated. In this study, we compared the retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), the inner plexiform layer (IPL), and choroid thickness (CT) of OUD and control groups. We included 43 male patients and 43 healthy male controls of similar age (p = 0.296) in the study, prospectively. On the day of OCT application, urine toxic screening test results of all OUD patients were positive for opioid use. There was a significant difference between OUD and control groups in terms of CT (p < 0.05), nasal superior (NS), and nasal (N) sectors of the RNFL (p < 0.05) values of both eyes. According to the binary logistic regression analysis, the sensitivity of mean NS (p = 0.001) and mean CT (p = 0.007) related to the diagnosis of OUD was 72.1 percent, and the specificity was 65.1 percent. Receiver operating characteristic (ROC) analysis revealed that the sensitivity and specificity of mean CT for the diagnosis of OUD were 18.6% and 97.7%, respectively. This is the first study to investigate the OCT findings in OUD. Our findings are important in terms of showing thinning in the choroidal layer and an increase in the volume of the NS and N sectors of RNFL while detecting opioids in the body/urine. Further studies are needed to clarify whether these differences are due to the acute and/or chronic effects of opioids.

摘要

物质使用障碍的光学相干断层扫描 (OCT) 检查的数量正在逐渐增加。然而，尚未对阿片类药物使用障碍 (OUD) 的 OCT 结果进行调查。在这项研究中，我们比较了 OUD 和对照组的视网膜神经纤维层 (RNFL)、神经节细胞层 (GCL)、内丛状层 (IPL) 和脉络膜厚度 (CT)。我们 前瞻性地在研究中纳入了 43 名男性患者和 43 名年龄相仿的健康男性对照 ( p = 0.296)。在 OCT 应用当天，所有 OUD 患者的尿毒筛查试验结果均为阿片类药物使用阳性。OUD与对照组在RNFL的CT（p  < 0.05），鼻上（NS）和鼻（N）扇区方面存在显着差异（p < 0.05) 双眼值。根据二元逻辑回归分析，平均NS（p  =0.001）和平均CT（p  =0.007）与OUD诊断相关的敏感性为72.1%，特异性为65.1%。受试者工作特征（ROC）分析显示平均 CT 诊断 OUD 的敏感性和特异性分别为 18.6% 和 97.7%。这是第一项调查 OUD 中 OCT 结果的研究。我们的发现在显示脉络膜层变薄和 RNFL 的 NS 和 N 扇区体积增加方面很重要，同时检测身体/尿液中的阿片类药物。需要进一步研究来澄清这些差异是否是由于阿片类药物的急性和/或慢性影响。