Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials,Cell Proliferation

当前位置： X-MOL 学术 › Cell Prolif. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-02-08 , DOI: 10.1111/cpr.12982
Huanhuan Lv _{1,

2,

3,

4} , Junyu Liu _{1,

3,

4} , Chenxiao Zhen _{1,

3,

4} , Yijia Wang _{1,

3,

4} , Yunpeng Wei ₃ , Weihao Ren _{1,

3,

4} , Peng Shang _{1,

3,

4}

Affiliation

Diabetes mellitus (DM) is a chronic metabolic disorder with various complications that poses a huge worldwide healthcare burden. Wounds in diabetes, especially diabetic foot ulcers (DFUs), are difficult to manage, often leading to prolonged wound repair and even amputation. Wound management in people with diabetes is an extremely clinical and social concern. Nowadays, physical interventions gain much attention and have been widely developed in the fields of tissue regeneration and wound healing. Magnetic fields (MFs)‐based devices are translated into clinical practice for the treatment of bone diseases and neurodegenerative disorder. This review attempts to give insight into the mechanisms and applications of MFs in wound care, especially in improving the healing outcomes of diabetic wounds. First, we discuss the pathological conditions associated with chronic diabetic wounds. Next, the mechanisms involved in MFs’ effects on wounds are explored. At last, studies and reports regarding the effects of MFs on diabetic wounds from both animal experiments and clinical trials are reviewed. MFs exhibit great potential in promoting wound healing and have been practised in the management of diabetic wounds. Further studies on the exact mechanism of MFs on diabetic wounds and the development of suitable MF‐based devices could lead to their increased applications into clinical practice.

中文翻译：

基于动物实验和临床试验的磁场作为糖尿病伤口的潜在疗法

糖尿病（DM）是一种慢性代谢性疾病，伴有各种并发症，给全球带来了巨大的医疗负担。糖尿病造成的伤口，尤其是糖尿病足溃疡（DFU）很难处理，常常导致伤口修复时间延长，甚至截肢。糖尿病患者的伤口处理是一个极其临床和社会关注的问题。如今，物理干预备受关注，并在组织再生和伤口愈合领域得到广泛发展。基于磁场（MF）的设备已转化为治疗骨病和神经退行性疾病的临床实践。本综述试图深入了解 MF 在伤口护理中的机制和应用，特别是在改善糖尿病伤口的愈合效果方面。首先，我们讨论与慢性糖尿病伤口相关的病理状况。接下来，探讨 MF 对伤口影响的机制。最后，回顾了动物实验和临床试验中有关 MF 对糖尿病伤口影响的研究和报告。MF 在促进伤口愈合方面表现出巨大的潜力，并已在糖尿病伤口的治疗中得到实践。对 MF 对糖尿病伤口的确切机制的进一步研究以及合适的基于 MF 的设备的开发可能会导致其在临床实践中的更多应用。

更新日期：2021-03-09

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11