This study aimed to evaluate the concentration of proprotein convertase subtilisin/kexin type-9 (PCSK9) and the activities of paraoxonase 1 in women with and without polycystic ovary syndrome (PCOS). We found significant higher PCSK9, whereas lower high-density lipoprotein concentration in the serum of women with PCOS when compared to the group without PCOS. Also paraoxonase 1 activities were significantly different between women with PCOS than without PCOS. In addition, the women with PCOS and insulin resistance had higher concentrations of PCSK9 than women with PCOS and insulin sensitivity. Higher PCSK9 concentration in the group with PCOS could be also associated with hormones concentrations.

Changes in paraoxonase 1 activities and lipid profile parameters as well as higher concentration of PCSK9 in the group of women with PCOS could be associated with metabolism disorders, but due to the small clinical sample size, the study should be continued.

本研究旨在评估患有和不患有多囊卵巢综合征（PCOS）的女性的原蛋白转化酶枯草杆菌蛋白酶/ kexin型9（PCSK9）浓度和对氧磷酶1的活性。我们发现与没有PCOS的女性相比，患有PCOS的女性的血清中PCSK9明显更高，而血清中的高密度脂蛋白浓度却较低。患有PCOS的女性与不患有PCOS的女性相比，对氧磷酶1的活性也有显着差异。此外，患有PCOS和胰岛素抵抗的女性比患有PCOS和胰岛素敏感性的女性具有更高的PCSK9浓度。PCOS组中较高的PCSK9浓度也可能与激素浓度有关。

患有PCOS的女性人群中对氧磷酶1活性和脂质谱参数的变化以及PCSK9的较高浓度可能与代谢异常有关，但由于临床样本量较小，应继续进行研究。