Immune checkpoint inhibition has revolutionized the treatment of many cancers, including melanoma. However, primary and acquired resistance remain key challenges for the field. Promising results from a phase I clinical trial recently published in Science highlight the potential of modulating the microbiome via fecal transplant to overcome resistance to immunotherapy.

中文翻译：

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针对微生物组克服耐药性

免疫检查点抑制已经彻底改变了许多癌症的治疗，包括黑色素瘤。然而，原发性和获得性耐药性仍然是该领域面临的主要挑战。最近发表在《科学》杂志上的I 期临床试验的有希望的结果强调了通过粪便移植调节微生物组以克服对免疫疗法的抵抗力的潜力。